NMN is the most researched science-backed anti-ageing supplement that keeps your cells young by boosting NAD⁺ levels, your cells’ fuel. NMN is naturally-occuring in our bodies, it is needed to support a longer healthier life.
NMN
LOWER YOUR BIO AGE
NMN is the most researched science-backed anti-aging supplement that keeps your cells young by boosting NAD⁺ levels, your cells’ fuel. NMN is naturally-occuring in our bodies, it is needed to support a longer healthier life.
AGING & MUSCLE LOSS
How Muscle Loss Progress Throughout Lifetime?
Muscle loss, also known as muscle atrophy is a natural process that occurs throughout our lifetime but the rate and extent of muscle loss can vary depending on various factors including age, activity level, and overall health. Muscle mass begins to decline at a rate about 3-8% per decade after 30 and tends to accelerate after the age of 50. Some studies indicate a loss up to 1-2% of muscle mass per year. Preserving muscle mass is a lifelong endeavor, and starting early with these healthy habits can significantly impact our muscle health as we age.
Ways to Defy Muscle Loss
Clinical study has shown that, NMN increase NAD⁺ levels inside body which is critical for sustaining muscle functions both in physiological and pathological conditions.
Muscle atrophy is the wasting thinning or loss of muscle tissue
Physiologic atrophy is caused by not using the muscles enough. This type of atrophy can often be reversed with exercise and better nutrition. People who are most affected are those who:
- Have seated jobs, health problems that limit movement, or decreased activity levels.
- Are bedridden.
- Cannot move their limbs because of stroke or other brain disease.
- Are in a place that lacks gravity, such as during space flights.
Efficacy of CaHMB Supplementation on Enhancing Muscle Strength & Function:
The Health Benefits of Increasing NAD⁺ Levels
Muscle atrophy is the wasting thinning or loss of muscle tissue
Physiologic atrophy is caused by not using the muscles enough. This type of atrophy can often be reversed with exercise and better nutrition. People who are most affected are those who:
1
Have seated jobs, health problems that limit movement, or decreased activity levels.
2
Are bedridden.
3
Cannot move their limbs because of stroke or other brain disease.
4
Are in a place that lacks gravity, such as during space flights.
NMN supplementation in your diet helps to support healthy aging by promoting NAD⁺ levels in the body.
The Health Benefits of Increasing NAD⁺ Levels
Ways to Defy Muscle Loss
Clinical study has shown that, NMN increase NAD⁺ levels inside body which is critical for sustaining muscle functions both in physiological and pathological conditions.
The Ultimate Muscle Atrophy Inhibitor
BETMUSCLE
Active Ingredients
CaHMB
Beta-Hydroxy Beta-Methylbutyrate, commonly known as HMB, is a naturally occurring metabolite of the essential amino acid leucine. It has been shown to have anti-catabolic properties. It also helps reduce muscle protein breakdown and supports muscle repair and growth, promoting optimal muscle function by preserving muscle during prolonged endurance training.
- Minimizes muscle protein breakdown in periods of muscle training or caloric restriction
- Increases protein synthesis simultaneously enhance strength and power output
- Reduces muscle damage caused by exercise which can aid in faster recovery
- Preserves muscle mass and strength in older adults
- HMB might helps reduce age-related mental decline
VITAMIN D3 & K2
Vitamin D3, obtained from sunlight and foods like fatty fish. Vitamin K2, vital for bone and heart health, is found in fermented foods, egg yolks, and liver. Combining K2 with D3 offers added benefits, promoting a holistic nutritional approach
- Assists in binding and absorption of calcium and phosphorus to bone and teeth
- Prevents calcium from depositing in the arteries (arterial calcification)
- Ensures the calcium absorbed from the gut is directed to the bones
- Plays role in mood regulation and potential brain health regulation
L-LEUCINE
L-Leucine is one of the three branched-chain amino acids (BCAAs). It's an essential amino acid, which could not be produced by the human body. Among the BCAAs, L-Leucine stands out for its unique ability to stimulate muscle protein synthesis. L-Leucine also play roles in regulating blood sugar levels, producing growth hormones, and supporting wound healing.
- Initiates muscle protein synthesis through activation of mTOR pathway
- Supports wound healing, acts as building blocks for tissue repair and regeneration
- Reduces muscle protein breakdown (anti-catabolic property)
- Regulates blood sugar levels by modulating insulin secretion
Based off science & feedbacks from MotoGene users. Here are the results you can expect
NMN RESULTS
A human clinical study examining NMN supplementation at a dose of 250 mg per day in healthy adults significantly increase and sustain the levels of NAD⁺ in whole blood compared to placebo at 4 weeks.(4)
NMN is quickly absorbed from the gut into blood circulation within 2–3 min and absorbed into the tissues, immediately stored as NAD⁺ in various tissues such as liver, skeletal muscle, and cortex. (1)(2)
Supplementing with 250 - 500mg of NMN daily enhances muscle function and mobility on elderly after 3 months. One clinical trial found an improvement in walking speed in healthy, elderly men who took 250 mg of NMN per day.(7)
One clinical study of prediabetic women who ingest 250mg of NMN per day had shown increment in NMN metabolites in skeletal muscle tissue, suggesting that the muscles were using more NAD⁺. This finding also suggested that NMN may support healthy insulin sensitivity in skeletal muscle.(6)
A small clinical trial involving healthy postmenopausal women found that NMN supplementation for eight weeks at 300 mg of NMN per day resulted in decreased AGEs in the skin.(5)
Cell power house mitochondria benefit from NAD⁺ increment. A preclinical study demonstrated that treatment of human kidney cells in culture with NMN for three days resulted in increased mitochondrial replication.(3)
Based off science & feedbacks from MotoGene users. Here are the results you can expect
NMN RESULTS
NMN is quickly absorbed from the gut into blood circulation within 2–3 min and absorbed into the tissues, immediately stored as NAD⁺ in various tissues such as liver, skeletal muscle, and cortex. (1)(2)
Cell power house mitochondria benefit from NAD⁺ increment. A preclinical study demonstrated that treatment of human kidney cells in culture with NMN for three days resulted in increased mitochondrial replication.(3)
A human clinical study examining NMN supplementation at a dose of 250 mg per day in healthy adults significantly increase and sustain the levels of NAD⁺ in whole blood compared to placebo at 4 weeks.(4)
A small clinical trial involving healthy postmenopausal women found that NMN supplementation for eight weeks at 300 mg of NMN per day resulted in decreased AGEs in the skin.(5)
One clinical study of prediabetic women who ingest 250mg of NMN per day had shown increment in NMN metabolites in skeletal muscle tissue, suggesting that the muscles were using more NAD⁺. This finding also suggested that NMN may support healthy insulin sensitivity in skeletal muscle.(6)
Supplementing with 250 - 500mg of NMN daily enhances muscle function and mobility on elderly after 3 months. One clinical trial found an improvement in walking speed in healthy, elderly men who took 250 mg of NMN per day.(7)
FREQUENTLY ASKED QUESTIONS
The recommended daily intake for adults aged 18 and above is 1--2 sachets, with a maximum limit of 4 sachets. Consult a healthcare professional before use, particularly if you have any underlying health conditions.
Pre-exercise: 30 to 60 minutes prior to exercise might help in reducing muscle damage and improving recovery post-exercise
Post exercise: Right after exercise to promote muscle protein synthesis and muscle recovery
Non-training days: Timing is flexible but we recommend taking BetMuscle before breakfast
According to principal investigator John Rathmacher, Ph.D., “It is unrealistic to simply increase dietary protein intake because, as we age, our bodies lose the ability to respond effectively to certain signals, such as those triggered by protein consumption or exercise. As a result, older adults require more protein or exercise to achieve the same muscle growth response.”
HMB plays a crucial role in supporting muscle health in older adults by simultaneously stimulating protein synthesis and reducing muscle breakdown. Additionally, higher vitamin D levels are linked to greater strength and improved muscle function, particularly in aging individuals. “With this study, we now understand that HMB and vitamin D3 can work synergistically in older adults, producing superior benefits compared to either nutrient alone,” Rathmacher concluded [10].
Additionally, NMN has been shown to elevate blood NAD+ levels in aged individuals, leading to improved muscle function and increased mobility.
The key ingredients of BetMuscle are CaHMB and NMN.
CaHMB enhances muscle protein levels through two primary mechanisms:
- Reducing protein breakdown: HMB helps minimize muscle degradation caused by intense workouts by inhibiting the ubiquitin-proteasome proteolytic pathway.
- Increasing protein synthesis: Research suggests that HMB stimulates protein synthesis through multiple mechanisms, including activation of the mTOR pathway, leading to greater strength and muscle growth.
NMN, a precursor to the essential coenzyme NAD+, plays a pivotal role in muscle function by:
- Enhancing mitochondrial energy production, which fuels muscle performance and endurance.
- Aiding muscle repair through the activation of sirtuins, proteins crucial for DNA repair and cellular health.
- Combating age-related muscle atrophy by supporting protective pathways and improving blood flow to muscles. NMN may also boost nitric oxide production, facilitating better oxygen and nutrient delivery to muscle tissues.
To date, there is no direct evidence indicating harmful interactions between CaHMB and protein powder, BCAAs, creatine, or pre-workout supplements. However, for any other supplements not mentioned, it is always advisable to research their mechanisms of action and potential interactions before combining them. Consulting a healthcare professional or a nutrition expert can also help ensure safe and effective supplementation.
There are two common methods for manufacturing NMN:
- Chemical synthesis: Labor-intensive and expensive. This method yields a high throughput and allows for precise control of the starting materials, though none are sourced from biological systems. It uses environmentally damaging solvents, and impurities or byproducts in the finished product can be difficult to remove.
- Enzymatic synthesis: Although costly, this method produces a higher yield and exceptional purity. It is considered a green preparation method for the production of NMN.
MotoGene's BetMuscle NMN is produced using enzymatic synthesis. Our products undergo microbiology analysis and heavy metal testing (for lead, mercury, and arsenic), conducted by third-party laboratories to ensure consumption safety. High-quality NMN is the primary reason why our consumers experience health benefits as quickly as 14 days of consuming MotoGene's NMN.
The ingredients in BetMuscle are generally considered safe for consumption. However, in rare cases, some individuals may experience mild side effects such as stomach upset, diarrhea, headache, or nausea, especially if exceeding the recommended dosage.
For those taking medication for hypertension or with a history of blood pressure irregularities, it is advisable to monitor blood pressure regularly and consult a qualified healthcare professional before use.
- Individuals who are allergic to vitamin B3
- Individuals who are undergoing kidney dialysis
- Individuals with gout (uric acid reading above 7.5mg/dL)
- Individuals with low blood sugar complications
- Individuals who take anticoagulants drugs (e.g: warfarin)
- Limited data on pregnant or breastfeeding women
Individuals using BetMuscle for muscle recovery after intense exercise may notice effects sooner than those using it for gradual muscle mass gain. To fully assess its potential benefits, we recommend following a consistent regimen for 1–3 months.
The speed and extent of results can vary based on metabolism, overall health, diet, exercise routine, and other lifestyle factors. Consistency in supplementation, combined with a well-balanced diet and regular exercise, will help maximize the benefits.